Table 4. Multivariable Cox regression analysis for DFS.

	Univariate Cox-Regression		Multivariable Cox-Regression
Variable	HR (95% CI)	p	HR (95% CI)	p
HTRA1expression (low/high)	0.55 (0.32–0.94)	0.028	0.46 (0.23–0.92)	0.028
Nodal status (negative/positive)	1.39 (0.79–2.46)	0.256	2.12 (1.07–4.22)	0.032
Tumor stage (pT1+2/pT3+4)	2.11 (1.09–4.09)	0.027	1.29 (0.50–3.33)	0.597
Age at diagnosis (<50 ys/>50 ys)	0.72 (0.37–1.39)	0.329	0.54 (0.25–1.17)	0.119
Nuclear grading (G1+2/G3)	1.23 (0.69–2.21)	0.489	1.21 (0.59–2.51)	0.606

Number of patients in multivariable analysis: n = 80; number of events of recurrence and/or death in multivariable analysis: 38.

For both analyses, binary variables are used; HR, hazard ratio; 95% CI, 95% confidence interval.

DFS: disease-free survival with endpoints recurrence and/or death.