Skip to main content
. Author manuscript; available in PMC: 2013 Apr 9.
Published in final edited form as: Lab Invest. 2009 Jun 1;89(8):903–914. doi: 10.1038/labinvest.2009.51

Figure 1.

Figure 1

SRC-3−/− mice are protected against liver necrosis after acute CCl4 administration. (a) Representative H&E stained liver sections from SRC-3+/+ and SRC-3−/− mice 24, 36, 48 and 72 hours after acute CCl4 administration. Liver necrosis in SRC-3−/− mice was significantly alleviated compared to SRC-3+/+ mice 48 hours after the insult (×100 magnification). (b) ALT serum concentrations in SRC-3+/+ and SRC-3−/− mice 24, 36, 48 and 72 hours after acute CCl4 administration. Note the significant reduction in serum ALT level in SRC-3−/− mice compared to SRC-3+/+ mice 48 hours after the insult. (c) Western blot analysis of TGFβ1, Collagen Type I and α-SMA expression levels in livers from SRC-3+/+ and SRC-3−/− mice 24, 36, 48 and 72 hours after acute CCl4 administration. GAPDH was used as an invariant control. All data are mean ± standard error. * *P<0.01, WT vs KO.