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. 2013 Apr 8;210(4):805–819. doi: 10.1084/jem.20121482

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© 2013 Parameswaran et al.

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Figure 9. — Esterase treatment has minimal effect on cells other than ALL. (A) Viability of malignant cells as indicated transduced with the inducible esterase lentiviral construct (pTuner-esterase-Puro) cultured in the presence or absence of Shield-1. (B) Viability of BM from an ALL patient after an overnight incubation with 20 µg/ml CHE-Fc compared with BM and PB from normal donors. Untreated cells (−CHE-Fc) serve as controls. (C) Viability of primary MEFs and HBMECs transduced with an inducible esterase lentiviral construct (pTuner-esterase-GFP). More than 90% of transduced cells were EGFP positive. ***, P < 0.001 for ALL BM −CHE-Fc compared with +CHE-Fc. Experiments were performed once. Error bars show the standard deviation of triplicate samples.