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. 2013 Apr 8;210(4):743–755. doi: 10.1084/jem.20121190

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© 2013 Curran et al.

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Figure 7. — IL-27, IL-10, and IL-15 knockout mice are defective in developing the cytotoxic Eomes⁺KLRG1⁺ T cell phenotype. Wild-type or knockout mice of the indicated phenotype were challenged with B16 melanoma and vaccinated with FVAX + α4-1BB with or without αCTLA-4. Tumor-infiltrating T cells were isolated on day 16 and analyzed by flow cytometry. For CD4 FoxP3⁺ T cells the MFI of Eomes staining (A) and the percentage of KLRG1⁺ cells (B) are shown. Also, the MFI of Granzyme B staining for these CD4 cells (C), as well as for CD8 T cells (D), is shown. Knockout mouse data are shown as the mean ± SEM for 3–10 experiments with 3–10 mice per group.