Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2013 Apr 8;210(4):821–838. doi: 10.1084/jem.20122005

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2013 D’Antonio et al.

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).

PMC Copyright notice

Figure 5. — Inactivation of Gadd34 restores motor function and ameliorates the neurophysiological and morphological deficits in S63del mice. (A) Rotarod analysis of motor function in WT, Gadd34^Δc/Δc, S63del and S63del/Gadd34^Δc/Δc. Error bars, SEM; *, P < 0.05; **, P < 0.01 for S63del/Gadd34^Δc/Δc relative to S63del; n = 20–25 animals. (B and C) Electrophysiological analysis showing NCV and F-wave latency; n = 10–12 animals; *, P < 0.05; **, P < 0.01, relative to S63del by Student’s t test. NCV, nerve conduction velocity. (D) Semithin sections stained with toluidine blue from P28 and P180 WT, S63del, and S63del/Gadd34^Δc/Δc sciatic nerves. Arrows, amyelinated axons in P28 S63del nerve. Arrowhead, demyelinated fiber/onion bulb in 6-mo-old S63del nerve. Bar, 10 µm. (E) Number of amyelinated axons at P28, and of demyelinated fibers (F) and onion bulbs (G) at 6 mo. Error bars, SEM; *, P < 0.05; **, P < 0.01; ***, P < 0.001, by Student’s t test; n = 20–35 microscopic fields from 4–6 animals per genotype.