Table 1.

Summary of the main pathways dysregulated in S63del nerves

	P5	P-value	P28	P-value	4 mo	P-value
Up-regulated pathways	UPR (stress)	2.1e-15	UPR (stress)	1.8e-7	Inflammation	2.7e-6
			Cell death	2.9e-5	Cell death	4.4e-4
					UPR (stress)	2.1e-3
	Early TFa (Oct6, Id2, Sox2)		Early TFa (Oct6, Id2, Sox2, c-Jun)		Early TF* (Oct6, Id2, Sox2, c-Jun)
Down-regulated pathways	Lipid biosynthesis	1.4e-35	Lipid biosynthesis	1.8e-7	Lipid biosynthesis	8.9e-4
	Sterol biosynthesis	5.6e-28	Sterol biosynthesis	2.7e-7	Sterol biosynthesis	4.7e-3
	Cholesterol biosynthesis	3.0e-26	Cholesterol biosynthesis	1.6e-4	Cholesterol biosynthesis	6.6e-3

Results are based on manual categorization and L2L analysis.

^aArbitrary category, not present in L2L or GO. For this reason, Early TF have no p-values.