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BM chimeric mice were created by transplanting (Tx) 129S6 or B6 BM into lethally irradiated Rag2−/− B6 or Rag2−/− 129S6 mice, respectively. The severity of glomerulonephritis induced by anti-MPO IgG was determined in the BM chimeras and the corresponding nonchimeric donor strains. The severity of crescent formation corresponded with the BM genotype, not the somatic genotype.
