Table 1.
Anti-MPO IgG–Induced Glomerular Lesions in Different Strains of Mice
| Strains | Mouse numbers, n | Mice with crescents, n | Mean % crescents when present | Mice with necrosis, n | Mean % necrosis when present |
|---|---|---|---|---|---|
| B6 | 27 | 27 | 9.5 | 27 | 4.0 |
| 129S6 | 24 | 24 | 63.7∗ | 24 | 22.4∗ |
| 129S1 | 22 | 22 | 21.1† | 21 | 7.3† |
| LP | 8 | 8 | 19.8 | 8 | 5.9 |
| WSB | 4 | 4 | 9.0 | 4 | 2.8 |
| NZO | 4 | 4 | 2.8 | 4 | 2.8 |
| PWK | 5 | 1 | 0.7 | 0 | NA |
| NOD | 4 | 0 | NA | 0 | NA |
| DBA1 | 5 | 2 | 0.9 | 0 | NA |
| DBA2 | 5 | 0 | NA | 0 | NA |
| AJ | 4 | 0 | NA | 0 | NA |
| C3H | 5 | 5 | 5.2 | 4 | 2.3 |
| CAST | 5 | 5 | 61.2 | 5 | 35.6 |
NA, not applicable; no crescents or necrosis was observed.
∗
P < 0.001 versus B6 and 129S1 mice.
†
P > 0.4 versus LP mice.