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. 2013 Apr;182(4):1248–1254. doi: 10.1016/j.ajpath.2012.12.024

Figure 1.

Figure 1

GRP blockade with 77427 abrogates peak CD68+ macrophages in mouse lungs at 4 weeks after radiation. A: Sham plus PBS group. CD68 immunostaining detects few alveolar and tissue macrophages in Sham controls (arrows). B: Radiation plus PBS group. After radiation there was a significant increase in CD68+ cells (arrowheads) in the alveolar interstitium. C: Radiation plus 77427 group. CD68+ cells diminished to baseline values in mice given 77427 twice a week after radiation. D: Image analysis. ∗ P < 0.00001 for radiation plus PBS versus either sham plus PBS, sham plus 77427, or radiation plus 77427. Scale bars: 25 μm (A–C). V, blood vessel.