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. 2013 Apr;182(4):1425–1433. doi: 10.1016/j.ajpath.2012.12.009

Figure 3.

Figure 3

FABP4 deficiency impairs cell proliferation in VEGF-TG mouse airways. A: WT, FABP4−/−, VEGF-TG, and VEGF-TG/FABP4−/− mice were given dox-water for 3 days. Tracheas were harvested, fixed in 10% formalin, embedded in paraffin, and immunostained for the proliferation marker Ki-67. Representative images are shown. B: Ki-67+ cell nuclei localized between the airway lumen and posterior border of the cartilage plates were counted and normalized to the area described. Bar graph represents means ± SEM values from 5 to 6 mice per group. ∗∗P < 0.01. C: Representative images of double immunofluorescence for CD31 and Ki-67 are shown. Arrows indicate colocalization of CD31 and Ki-67 in endothelial cells. Scale bars: 25 μm (B and C).