Table 1.
Effects of Missense and Null Trp53 Mutations on the Apc−/−;Pten−/− Tumor Phenotype
| Trp53 genotype | Tumor size (mm3) | Metastasis (n/N) | P∗ | Lung metastasis (n/N) | Median survival (days) | P† |
|---|---|---|---|---|---|---|
| LSL-R172H/+ | 4752.7 ± 1767.8 | 8/11 | 1/11 | 57 | ||
| 0.025 | 0.0001 | |||||
| +/+ | 4632.8 ± 2178.6 | 2/9 | 0/9 | 76 | ||
| R270H/+ | 4331.2 ± 1383.3 | 4/11 | 1/11 | 71 | ||
| 0.757 | 0.0227 | |||||
| +/+ | 4838.2 ± 1868.1 | 3/10 | 0/10 | 75 | ||
| flox/flox | 3068.7 ± 877.0 | 9/9 | 1/9 | 57 | flox/flox vs flox/+, 0.0006 | |
| flox/+ | 3137.6 ± 1536.9 | 6/8 | 0.016 | 0/8 | 64 | flox/flox vs +/+, 0.0004 |
| +/+ | 2422.8 ± 1351.7 | 2/6 | 0/6 | 69.5 | flox/+ vs +/+, 0.3482 |
flox, flox (del ex2-10).
∗
Determined by χ2 test.
†
Determined by log-rank test for median survival.