Table 2.
Effects of Mutant Pik3ca on the Phenotype of Ovarian Tumors with Mutant Pten, Apc, and/or Trp53 Alleles
| Genotype | No. | Normal | MOSE proliferation | Carcinoma | Peritoneal metastasis | Lung metastasis |
|---|---|---|---|---|---|---|
| Pten+/+;Pik3caLSL-E545K/+ | 4 | 4 | ||||
| Ptenflox/+;Pik3caLSL-E545K/+ | 3 | 3 | ||||
| Pik3caLSL-E545K/+;Trp53R270H/+ | 4 | 4 | ||||
| Ptenflox/flox;Pik3caLSL-E545K/+ | 11 | 11 | ||||
| Ptenflox/flox;Pik3caLSL-E545K/+;Trp53LSI-R172H/+ | 5 | 5 | ||||
| Apcflox/+;Ptenflox/flox;Pik3caLSL-E545K/+ | 5 | 3 | 2 | |||
| Apcflox/flox;Ptenflox/+;Pik3caLSL-E545K/+ | 6 | 2 | 4 | |||
| Apcflox/flox;Ptenflox/flox;Pik3caLSL-E545K/+ | 11 | 11 | 7 | 1 | ||
| Apcflox/flox;Ptenflox/flox | 11 | 11 | 4 |