Table 2.

Quantification of Immunohistochemical Analysis in LPS Xenografts

Marker and xenograft	Staining score (density/intensity)∗
	Vehicle	Rapamycin	Sorafenib	Combination
p-S6
LPSX1	2/3+	1/1+	2/2+	1/1+
LPSX2	2/3+	1/1+	2/2+	1/1+
LPSX3	2/3+	1/1+	2/2+	1/1+
p-ERK
LPSX1	2/2+	3/2+	3/2+	3/2+
LPSX2	1/1+	1/1+	2/3+	2/1+
LPSX3	2/1+	2/1+	2/2+	2/1+

^∗Staining density is scored as <1, negative staining; 1, 1% to 25% of tumor cells staining; 2, 26% to 74% of tumor cells staining; 3, ≥75% of tumor cells staining. Staining intensity is scored as 1+, weak; 2+, moderate; 3+, strong.