Table 2.

Light Microscopic Findings after Challenge with Stx1 or Stx2

Glomeruli						Tubulointerstitium
Toxin	Dose (ng/kg)	Survival (h)	Endocap infil	Mesangial apoptosis	Mesangial mitosis	Distension	Epithelial flattening	Tubular pyelo. (poly)	Interstit hemor	Tubular epithelial prolif./mitoses
Stx1	10	168∗	0	0	0	0	0	0	0	0
	10	168∗	0	0	0	0	0	0	0	0
	10	168∗	0	0	0	0	0	0	0	0
	50	58	0	0	0	1	1	0	0	0
	50	72	0	0	0	1	1	0	0	0
	50	72	0	1	0	1	1	0	0	0
	50	74	0	0	0	1	1	2F	0	0
	50	168∗	0	0	0	0	0	0	0	0
	100	48	0	0	0	1	1	0	0	0
	100	49.5	0	0	0	1	1	0	0	0
	100	57.5	0	0	0	2	2	0	0	0
	100	60	0	0	0	1	1	0	0	0
	100	72	0	0	0	2	2	0	0	0
Stx2	10	111.2	0	3	0	1	1	2F	3	0
	10	288∗	0	0	0	0	0	0	0	0
	10	672∗	0	0	0	0	0	0	0	0
	10	720∗	1F(1)	0	0	0	0	0	0	0
	50	84	0	1FS	0	1	1	0	2†	+/−
	50	96	0	2	1	1	0	0	2†	0
	50	96	0	0	0	0	0	1F	0	0
	50	112	0	4	0	2	2	0	4+	3
	50	121.6	0	4	0	2	2	1F	4+	2
	50	121.3	0	4	0	2	3	0	4+	4+
	50	128	0	3	0	2	2	1F	1F	2

Categories scored: +/− (occasional), 0 to 4+ where 0 = not observed and 4+ = most severe.

F, focal (otherwise diffuse); S, segmental (otherwise global).

^∗Time at necropsy of survivor (survivor is ≥168 hours).

^†Medulla only.