. 2013 Apr 8;8(4):e60851. doi: 10.1371/journal.pone.0060851

Table 2. Meta-analysis of the associations between ESR1 PvuII and XbaI polymorphisms and endometrial cancer risk.

Subgroups	2 allele vs. 1 allele (allele model)			1/2+2/2 vs. 1/1 (dominant model)			2/2 vs. 1/1+ ½ (recessive model)			2/2 vs. 1/1 (homozygous model)			2/2 vs. ½ (heterozygous model)
	OR	[95%CI]	P	OR	[95%CI]	P	OR	[95%CI]	P	OR	[95%CI]	P	OR	[95%CI]	P
rs2234693 (PvuII)
Overall	1.08	[1.00, 1.17]	0.043	1.12	[0.98, 1.28]	0.098	1.11	[0.98, 1.25]	0.091	1.18	[1.01, 1.38]	0.043	1.08	[0.95, 1.23]	0.243
Ethnicity
Caucasian	1.10	[1.01, 1.19]	0.030	1.12	[0.97, 1.30]	0.113	1.14	[1.00, 1.30]	0.047	1.21	[1.02, 1.43]	0.027	1.11	[0.97, 1.28]	0.129
Asian	1.00	[0.81, 1.24]	0.993	1.09	[0.77, 1.55]	0.615	0.92	[0.65, 1.30]	0.627	0.97	[0.62, 1.52]	0.902	0.88	[0.61, 1.28]	0.509
Source of controls
Population-based	1.12	[1.02, 1.23]	0.023	1.20	[1.02, 1.42]	0.027	1.12	[0.97, 1.30]	0.116	1.26	[1.04, 1.53]	0.017	1.07	[0.92, 1.25]	0.400
Hospital-based	1.02	[0.89, 1.17]	0.792	0.97	[0.78, 1.22]	0.771	1.08	[0.87, 1.34]	0.489	1.01	[0.77, 1.34]	0.941	1.11	[0.88, 1.40]	0.379
Genotype methods
PCR-RFLP	1.06	[0.91, 1.24]	0.473	1.13	[0.87, 1.48]	0.365	1.04	[0.81, 1.33]	0.767	1.12	[0.81, 1.54]	0.509	1.01	[0.77, 1.31]	0.968
DNA sequencing	1.17	[1.03, 1.32]	0.013	1.31	[1.06, 1.62]	0.014	1.18	[0.97, 1.42]	0.096	1.40	[1.09, 1.80]	0.009	1.09	[0.89, 1.33]	0.403
Other methods	1.01	[0.89, 1.15]	0.884	0.94	[0.75, 1.17]	0.557	1.09	[0.89, 1.33]	0.415	1.01	[0.78, 1.31]	0.950	1.12	[0.91, 1.39]	0.285
rs9340799 (XbaI)
Overall	1.07	[0.89, 1.29]	0.459^†	1.19	[0.97, 1.45]	0.099	1.07	[0.84, 1.36]	0.598^†	1.15	[0.79, 1.67]	0.464^†	1.11	[0.97, 1.27]	0.116
Ethnicity
Caucasian	1.07	[0.89, 1.29]	0.462	1.16	[0.93, 1.43]	0.183	1.10	[0.86, 1.40]	0.451	1.13	[0.79, 1.63]	0.500	1.14	[0.99, 1.31]	0.079
Asian	1.06	[0.58, 1.93]	0.850	1.45	[0.79, 2.67]	0.232	0.96	[0.46, 2.00]	0.921	1.38	[0.35, 5.41]	0.642	0.94	[0.63, 1.42]	0.783
Source of controls
Population-based	1.09	[0.88, 1.36]	0.435	1.17	[0.93, 1.48]	0.173	1.13	[0.87, 1.48]	0.368	1.17	[0.76, 1.81]	0.476	1.15	[0.99, 1.33]	0.055
Hospital-based	1.04	[0.70, 1.54]	0.848	1.23	[0.80, 1.88]	0.345	0.94	[0.56, 1.58]	0.828	1.15	[0.50, 2.65]	0.739	0.91	[0.64, 1.29]	0.600
Genotype methods
PCR-RFLP	1.07	[0.82, 1.40]	0.607	1.17	[0.84, 1.62]	0.349	1.03	[0.72, 1.48]	0.861	1.15	[0.68, 1.95]	0.609	1.06	[0.84, 1.35]	0.625
DNA sequencing	1.26	[1.10, 1.46]	0.001	1.41	[1.03, 1.93]	0.033	1.33	[1.10, 1.60]	0.003	1.59	[1.14, 2.21]	0.006	1.28	[1.05, 1.55]	0.015
Other methods	0.88	[0.72, 1.09]	0.243	0.82	[0.51, 1.31]	0.402	0.87	[0.66, 1.14]	0.302	0.77	[0.48, 1.26]	0.303	0.89	[0.67, 1.18]	0.417

OR = odds ratios; 95%CI = 95% confidence interval; 1 = wild allele; 2 = mutant allele; 1/1 = wild homozygote; 1/2 = heterozygote; 2/2 = mutant homozygote; P_h = P value of heterogeneity test; † = estimates for random effects model.