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. 2013 Apr 8;8(4):e60817. doi: 10.1371/journal.pone.0060817

Figure 7. Minocycline inhibits metastatic capacity of SKOV-3 cells along with down-regulation of MMP-2 and MMP-9.

Figure 7

The effects of minocycline on SKOV-3 (A) cell migration and (B) invasion was measured by Transwell assay. Minocycline was applied at different concentrations (0–100 µM) for 18 h. (C) Expression of MMP-2 and MMP-9 estimated by western blot analysis after 18 h treatment of SKOV-3 cells with varying concentration of minocycline. (D) Cell adhesion following 18 h exposure to varying concentrations of minocycline as described in MATERIAL AND METHODS (*p<0.05, **p<0.01 and ***p<0.001 vs. control).