Table 1.
Enzymatic activity | Sub-cellular localization | Effects on AD | Targets related to AD | |
---|---|---|---|---|
SIRT1 | Deacetylase | Nuclear, cytoplasmic | Neuroprotective (Chen et al., 2005; Qin et al., 2006b; Kim et al., 2007; Julien et al., 2009; Donmez et al., 2010; Min et al., 2010) | RARb, Tau, PGC1a, LXR, NFkB |
SIRT2 | Deacetylase | Cytoplasmic, nuclear | Genetic association (Polito et al., 2012) | Unknown |
SIRT3 | Deacetylase | Mitochondrial | Genetic association (Weir et al., 2012) | Unknown |
SIRT4 | Deacetylase ADP-ribosyltransferase | Mitochondrial | Unknown | Unknown |
SIRT5 | Deacetylase Demalonylase Desuccinylase | Mitochondrial | Unknown | Unknown |
SIRT6 | ADP-ribosyltransferase Deacetylase | Nuclear | Unknown | Unknown |
SIRT7 | Deacetylase | Nucleolar | Unknown | Unknown |