Table 1.

Activity and localization of mammalian sirtuins and their effects on AD.

	Enzymatic activity	Sub-cellular localization	Effects on AD	Targets related to AD
SIRT1	Deacetylase	Nuclear, cytoplasmic	Neuroprotective (Chen et al., 2005; Qin et al., 2006b; Kim et al., 2007; Julien et al., 2009; Donmez et al., 2010; Min et al., 2010)	RARb, Tau, PGC1a, LXR, NFkB
SIRT2	Deacetylase	Cytoplasmic, nuclear	Genetic association (Polito et al., 2012)	Unknown
SIRT3	Deacetylase	Mitochondrial	Genetic association (Weir et al., 2012)	Unknown
SIRT4	Deacetylase ADP-ribosyltransferase	Mitochondrial	Unknown	Unknown
SIRT5	Deacetylase Demalonylase Desuccinylase	Mitochondrial	Unknown	Unknown
SIRT6	ADP-ribosyltransferase Deacetylase	Nuclear	Unknown	Unknown
SIRT7	Deacetylase	Nucleolar	Unknown	Unknown