Atherosclerotic lesion (HE, ×400 magnification) on the aortas in mice fed with diets varying in methionine for 15 weeks. The cross-sections were from aortas from each group, and these were chosen from mice whose average lesion area approximated the mean value for that group. The arrows indicate atherosclerotic plaques. (A) blank control group; (B) ApoE−/− control group; (C) HM group; (D) HM+FA+VB group. HE, hematoxylin and eosin; ApoE−/−, apolipoprotein E–deficient; FA, folic acid; VB, vitamin B12.