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Comparison of the three thioredoxin reductases discussed in this study. The M. tuberculosis. TrxR shows 45% identity and 63% homology to the E. coli TrxR and 14% identity and 22% homology to human TrxR1. ○ denotes active site cysteines. ∅ denotes cysteines that form mixed disulfides between the thioredoxin and thioredoxin reductase. ⊙ denotes the selenocysteine from human thioredoxin reductase.
