Effects of CAP application are reflected in the magnitude of compound C-fiber response in the digital nerve. A - MUA was recorded prior to application of CAP (Baseline), and 10, 20 and 30-45 days after application and averaged across 5 rats. B – a decrease in total magnitude of the C-fiber compound response within the range of NCV 0.5-2 m/s after treatment with CAP (ANOVA p< 0.03, closed bars, mean, SEM, N=5) is compared to no change of the same measure in age-matched controls (open bars, mean, SEM, N=5). For illustration purposes averaged MUA was smoothed.