Table 1.

Selected genes that were regulated by Aggregatibacter actinomycetemcomitans or Porphyromonas gingivalis.

Gene	Fold change A.a. (MOI 10)	p/q value	Fold change P.g. (MOI 10)	p/q value
Cytokines
Interleukin-1 alpha	32.0±0.16a)	<1x10−5	9.4±0.15a)	<1×10−5
Interleukin-1 beta	18.0±0.26a)	<1×10−5	9.0±0.25a)	<1×10−5
Interferon-alpha	5.4±2.16b)	<1×10−5,a) / <0.05b)	1.1±0.89b)	<1×10−5,a) / 0.42b)
Interferon-beta	9.9±2.57b)	<1×10−5,a) / 0.01b)	0.04±0.1b)	<1×10−5,a) / <0.05b)
Interferon regulatory factor 7a)	1.3±0.21a)	<1×10−5	6.2±0.2a)	0.033
IL-6	30.4±0.21a)	<1×10−5	10.8±0.21a)	0.53
IL-10	42.0±0.3a)	<1×10−5	3.26±0.3a)	<1×10−5
IL-12	20.0±0.19a)	<1×10−5	12.0±0.18a)	<1×10−5
IL-23, p19	18.8±0.15a)	<1×10−5	1.1±0.14a)	<1×10−5
Surface receptors
Interleukin-2R *** chain (CD25)	4.16±0.16a)	<1×10−5	1.5±0.16a)	0.0015
Antigen presentation
CD1d	1.7±0.15a)	0.995	1.2±0.15a)	<1×10−5
CD40		<1×10−5	1.5±0.22a)	<1×10−5
histocompatibility 2, class II Mb2	4.0±0.14a)	<1×10−5	1.4±0.14a)	0.0077
histocompatibility 2, D region, locus 1	2.0±0.22a)	<9×10−5	1.5±0.22a)	0.0074
histocompatibility 2, Q region locus 8	3.4±0.1a)	<1×10−5	1.4±0.09a)	0.0035

^a)microarray;

^b)Q-PCR. Data are displayed as means plus/minus SEM. Note that the standard errors for array data tend to be relatively small due to the pre-normalization and the linear modeling.

Statistical analysis of the data was performed using unpaired t-tests (qPCR data) or Bayesian statistics and linear modeling using Bioconductor/limma (microarray data). p values (qPCR) and q values (array data) are displayed.