Table 3.
Association of CYP3A genetic polymorphisms and asthma control scores among children receiving daily inhaled fluticasone propionate
| Polymorphism | Reference SNP (rs #) |
Test for Hardy Weinberg Equilibrium (P-value) |
Variant Allele Frequency |
Association with Asthma Control Scores (P-value) ⊗ |
|---|---|---|---|---|
| CYP3A4 | ||||
| CYP3A4*22 | rs35599367 | 0.29 | 0.04 | 0.02 |
| CYP3A4 int 7 | rs2246709 | 0.12 | 0.33 | 0.42 |
| CYP3A4 int 7 | rs4646437 | 0.03 | 0.17 | 0.54 |
| CYP3A5 | ||||
| CYP3A5*3 | rs776746 | 0.33 | 0.15 | 0.51 |
| CYP3A5*6 | rs10264272 | 0.80 | 0.01 | 0.86 |
| CYP3A5*1D | rs15524 | 0.30 | 0.15 | 0.96 |
| CYP3A7 | ||||
| CYP3A7 | rs2687133 | 0.13 | 0.14 | 0.55 |
| CYP3A7*2 | rs2257401 | 0.04 | 0.15 | 0.50 |
| CYP3A7 6 nt 5′ of ex 14 | rs2740565 | 0.18 | 0.16 | 0.69 |
⊗
Bonferroni adjustment for multiple comparisons.