Table 3.
Relative changes of Ery-Cd and U-Cd concentrations depending on genotypes of TFRC rs3804141.
| Gene, SNP | Population | Genotypea | Ery-Cd | U-Cd | ||||
|---|---|---|---|---|---|---|---|---|
| n | Relative change (95% CI) | pTrend | n | Relative change (95% CI) | pTrend | |||
| TFRC | ||||||||
| rs3804141 | Andes | GG | 94 | 1 | 98 | 1 | ||
| GA | 52 | 1.01 (0.89, 1.14) | 53 | 1.22 (0.98, 1.51) | ||||
| AA | 15 | 1.11 (0.91, 1.35) | 0.6 | 16 | 1.56 (1.10, 2.20) | 0.006 | ||
| Bangladesh | GG | 179 | 1 | 267 | 1 | |||
| GA | 55 | 1.08 (0.92, 1.27) | 82 | 1.22 (1.01, 1.48) | ||||
| AA | — | 0.3 | 10 | 1.58 (0.97, 2.57) | 0.009 | |||
| —, Combined with the heterozygote genotype because the frequency of the homozygote genotype was very low (AA n = 5). Linear regression models adjusted for age and plasma ferritin. aReference genotype, GG, is the most common homozygote in Bangladesh. | ||||||||