Table 4.
Study population-specific relative changes of Ery-Cd and U-Cd concentrations depending on TF and TFR2 SNPs.
| Gene, SNP | Population | Genotypea | Ery-Cd | U-Cd | ||||
|---|---|---|---|---|---|---|---|---|
| n | Relative change (95% CI)b | p-Value | n | Relative change (95% CI) | p-Value | |||
| TF | ||||||||
| rs3811647 | Andes | GG | 32 | 1 | 0.5 | 32 | 1 | 0.009 |
| AG | 82 | 0.91 (0.78, 1.06) | 82 | 0.65 (0.50, 0.86) | ||||
| AA | 54 | 0.91 (0.78, 1.07) | 54 | 0.76 (0.57, 1.00) | ||||
| Bangladesh | GG | 76 | 1 | 0.5 | 109 | 1 | 0.2 | |
| AG | 116 | 1.01 (0.87, 1.18) | 181 | 0.93 (0.77, 1.11) | ||||
| AA | 34 | 1.14 (0.92, 1.41) | 58 | 1.14 (0.89, 1.45) | ||||
| rs12595 | Andes | AA | 30 | 1 | 0.5 | 30 | 1 | 0.01 |
| GA | 89 | 0.91 (0.78, 1.07) | 89 | 0.66 (0.50, 0.86) | ||||
| GG | 50 | 0.94 (0.80, 1.11) | 50 | 0.78 (0.58, 1.05) | ||||
| Bangladesh | AA | 82 | 1 | 0.5 | 116 | 1 | 0.1 | |
| GA | 114 | 1.0 (0.87, 1.17) | 182 | 0.91 (0.76, 1.09) | ||||
| GG | 36 | 1.1(0.91, 1.38) | 59 | 1.13 (0.89, 1.45) | ||||
| rs4459901 | Andes | TT | 40 | 1 | 0.9 | 40 | 1 | 0.036 |
| TC | 83 | 0.97 (0.84, 1.12) | 83 | 0.72 (0.56, 0.92) | ||||
| CC | 46 | 1.01 (0.86, 1.18) | 46 | 0.79 (0.60, 1.04) | ||||
| Bangladesh | TT | 91 | 1 | 0.7 | 143 | 1 | 0.5 | |
| TC | 111 | 1.04 (0.87, 1.34) | 158 | 1.05 (0.88, 1.25) | ||||
| CC | 31 | 1.08 (0.90, 1.21) | 57 | 1.15 (0.90, 1.47) | ||||
| TFR2 | ||||||||
| rs7385804 | Andes | AA | 114 | 1 | 0.1 | 114 | 1 | 0.0004 |
| CA/CCc | 52 | 0.91 (0.81, 1.02) | 52 | 0.68 (0.55, 0.84) | ||||
| Bangladesh | AA | 102 | 1 | 0.6 | 152 | 1 | 0.4 | |
| CA | 92 | 0.96 (0.83, 1.12) | 150 | 0.89 (0.74, 1.06) | ||||
| CC | 40 | 0.91 (0.75, 1.11) | 57 | 0.98 (0.77, 1.25) | ||||
| Linear regression models adjusted for age and plasma ferritin. aReference genotype is the most common homozygote in Bangladesh. bEry-Cd was measured in the Bangladeshi women and was estimated based on B-Cd concentrations for the Andean women. cThe CA and CC genotypes were combined because the frequency of the homozygote genotype was very low (CC n = 9). | ||||||||