Table II.
Some Proteins Reported in the Literature to Undergo Retinoylation
| Retinoylated Proteins | Tissues/Cell lines | Species | Implicated Diseases/Possible Roles | Citations |
|---|---|---|---|---|
|
| ||||
| Nuclear matrix proteins including p51 and p55 | Bone marrow | Rat | Aging | (26,28) |
|
| ||||
| Oxoglutarate carrier | Testes mitochondria | Rat | Testosterone biosynthesis/Steroidogenesis | (94) |
|
| ||||
| Thioredoxin reductase | Keratinocytes | Human | Inhibition of thioredoxin reductase | (95) |
|
| ||||
| Protein kinase (PKA) types I and II cyclic AMP-binding regulatory subunits | Human acute myeloid leukemia cell line (HL60) | Human | RA induced differentiation of HL60 cells to granulocyte-like cells | (96) |
| MCF-7 breast cancer cell line | Cell growth | (97) | ||
| Fibroblasts | Psoriasis | (98) | ||
|
| ||||
| Vimentin | Human acute myeloid leukemia cell line (HL60) and HL60 mutants | Human | RA induced differentiation of HL60 cells to granulocyte-like cells | (99,100) |
|
| ||||
| Actin binding protein (α-actinin) | Human acute myeloid leukemia cell line (HL60) | Human | RA induced differentiation of HL60 cells to granulocyte-like cells | (25) |
|
| ||||
| Basic proteins (Histone) | Human acute myeloid leukemia cell line (HL60) | Human | RA induced differentiation of HL60 cells to granulocyte-like cells | (101) |
|
| ||||
| Cytokeratins 16 and 10 | Skin | Mice | Normal skin function; Epidermal differentiation | (27) |
|
| ||||
| Serum albumin | Skin | Mice | Mediate in vivo response of RA | (27) |