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. 2013 Apr 9;3:1583. doi: 10.1038/srep01583

Table 3. Comparison of protein complexes over-expressed in brain tumor and their up-regulated component genes.

Complex name Also identified by GSEA Number of genes in complex Percentage of up-regulated genes in complex Number of genes associated with nerve system cancers Percentage of up-regulated genes in subset of genes associated with nerve system cancers
SMN complex, U7 snRNA specific Y 5 100% 0 -
CDC2-CCNA2 complex Y 2 50% 2 50%
VEGF transcriptional complex Y 5 40% 1 100%
Cell cycle kinase complex CDK5 Y 5 40% 5 40%
Anti-HDAC2 complex Y 17 17.65% 7 42.86%
Emerin complex 52 Y 23 17.39% 8 25%
RC complex during S-phase of cell cycle Y 13 7.69% 7 0
WINAC complex Y 14 7.14% 6 16.67%
EIF3 complex (EIF3B, EIF3G, EIF3I) Y 3 0 0 -
CAV1-VDAC1-ESR1 complex N 3 33.33% 3 33.33%
SMURF2-SMAD3-SnoN complex, TGF(beta)-dependent N 3 33.33% 2 0
VHL-TBP1-HIF1A complex N 3 33.33% 2 50%
RAF1-RAS complex, EGF induced N 4 25% 4 25%
P2X7 receptor signalling complex N 11 9.09% 5 20%
RNA polymerase II complex, chromatin structure  modifying N 18 0 5 0
MRN-TRRAP complex (MRE11A-RAD50-NBN-TRRAP  complex) N 4 0 2 0
PLC-gamma-1-SLP-76-SOS1-LAT complex N 4 0 2 0
PlexinA1-NRP1-SEMA3A complex N 3 0 2 0
SMARCA2/BRM-BAF57-MECP2 complex N 3 0 2 0
TRAP complex N 15 0 2 0
APP-TIMM23 complex N 2 0 1 0
BCL6-HDAC7 complex N 2 0 1 0
DNA polymerase alpha-primase complex N 4 0 1 0
MCM8-ORC2-CDC6 complex N 2 0 1 0
RICH1-PAR3-aPKC polarity complex N 3 0 1 0
APLG1-Rababtin5 complex N 3 0 0 0
BLM-TOP3A complex N 2 0 0 -
CTF18-CTF8-DCC1-RFC3 complex N 2 0 0 -
FEN1-9-1-1 complex N 4 0 0 -
Kinase-scaffold-phosphatase complex, PKA-AKAP79-CaN N 3 0 0 -
PPP4C-PPP4R2-Gemin3-Gemin4 complex N 3 0 0 -
Retrotranslocation complex N 2 0 0 -
RFC2-RIalpha complex N 2 0 0 -
TRAP-SMCC mediator complex N 7 0 0 -