Table 1.
Baseline N=542 |
Visit 04 N=252 |
Visit 11 N=387 |
|
---|---|---|---|
| |||
Mean (SD) | Mean (SD) | Mean (SD) | |
|
|||
Age (years) | 46.1 (2.7) | 50.2 (2.7) | 56.9 (2.8) |
Weight (kg) | 85.8 (21.8) | 87.9 (22.1) | 90.1 (22.2) |
Height (cm) | 163.5 (6.2) | 162.8 (5.8) | 162.6 (6.2) |
BMI (kg/m2) | 32.1 (8.0) | 33.2 (8.3) | 34.1 (8.4) |
Waist circumference (cm) | 94.1 (17.1) | 98.5 (17.6) | 102.3 (17.6) |
Hip circumference (cm) | 113.9 (16.2) | 115.4 (17.0) | 118.1 (16.9) |
Waist:hip ratio | 0.82 (0.07) | 0.85 (0.08) | 0.87 (0.08) |
Leptin (ng/mL) | 30.6 (18.3) | 34.4 (20.1) | ----- |
n (%) | n (%) | n (%) | |
|
|||
Knee Osteoarthritis | 98 (18.1%) | 109 (43.3%) | 251 (64.9%) |
K-L Score | |||
0 | 322 (59.4%) | 61 (24.2%) | 44 (11.4%) |
1 | 122 (22.5%) | 79 (31.4%) | 89 (23.0%) |
2 | 78 (14.4%) | 84 (33.3%) | 147 (38.0%) |
3 | 19 (3.5%) | 27 (10.7%) | 62 (16.0%) |
4 | 1 (0.2%) | 1 (0.4%) | 45 (11.6%) |
Obese (BMI ≥ 30 kg/m2) | 301 (56.1%) | 153 (61.5%) | 250 (64.6%) |
Race/Ethnicity | |||
African-American | 324 (59.8%) | 181 (71.8%) | 238 (61.5%) |
Caucasian | 218 (40.2%) | 71 (28.2%) | 149 (38.5%) |
Menopause Status | |||
Premenopausal | 271 (50.3%) | 11 (4.4%) | 0 (0.0%) |
Early Perimenopausal | 268 (49.7%) | 104 (41.4%) | 12 (3.1%) |
Late Perimenopausal | 0 (0.0%) | 37 (14.7%) | 15 (3.9%) |
Postmenopausal | 0 (0.0%) | 51 (20.3%) | 303 (78.3%) |
Hysterectomy | 0 (0.0%) | 22 (8.8%) | 52 (13.4%) |
Unknown, hormone use | 0 (0.0%) | 26 (10.4%) | 5 (1.3%) |
Hormone therapy use | 0 (0.0%) | 45 (17.9%) | 32 (8.3%) |
Current Smoker | 146 (27.3%) | 63 (25.1%) | 87 (22.5%) |