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. Author manuscript; available in PMC: 2014 May 1.
Published in final edited form as: Immunol Rev. 2013 May;253(1):216–236. doi: 10.1111/imr.12047

Fig. 4. Mechanism for the regulation of CD45 alternative splicing.

Fig. 4

The CD45 ARS is depicted in orange/red and the ESE in green. In resting cells, hnRNP L (L) regulates basal levels of exon 4 repression, while SRSF1 mediates basal levels of exon 5 inclusion. Exon 5 inclusion is further regulated at the level of transcription. CTCF binds to the exon 5 ESE at the DNA level and promotes Pol II pausing around that region to promote exon 5 inclusion. Upon activation hnRNP LL and PSF join hnRNP L at the exon 4 and 6 ARSs to promote further repression, while only hnRNP L and PSF associates to exon 5.