Table 1.

Summary of the functions individual miRNAs play in T cells

miRNA	Function	Reference
miR-10a	Associated with stable Tregs	(43)
	Restraining ability of iTreg to convert to Tfh	(44)
miR-29ab	Potent repression of IFN-γ (CD4)	(26)
	Repression of IFN-γ	(88)
	Repression of IFN-γ in a negative feedback loop	(73)
miR-146a	Promotes Treg function in high stress setting and suppresses IFN-γ production in CD4+ effector T cells	(79)
	Limits T-cell numbers	(80)
	Limits CD4+ and CD8+ T-cell activation and numbers by negatively regulating NF-κB pathway in negative feedback loop	(81)
miR-155	Pleiotropic effects on multiple cell types including regulation of T-helper differentiation, germinal center reaction, and cytokine production	(74)
	Pleiotropic effects on multiple cell types including B, T, and dendritic cells. Regulation of immune response and cytokine production	(75)
	Promotes competitive fitness of Tregs	(78)
	Promotes thymic Treg development but is largely dispensable for Treg function	(77)
	Cell-intrinsically required for Th1 and Th17 responses	(76)
	CD8+ T memory cell formation	(84)
	Intrinsic requirement for normal CD8+ T-cell responses to LCMV and L. monocytogenes	(85)
miR-17-92	Promotes T-cell expansion	(91)
	Promotes CD4+ T-cell expansion and Th1 function. Inhibits TGFβ-induced iTreg generation	(47)
	CD8+ T-cell memory formation (promotes short-lived terminal effector CD8+ T cells, inhibits memory CD8+ T cells	(86)
	Required for accumulation of antigen-specific Treg and IL-10 production	de Kouchkovsky et al., manuscript submitted
	Regulation of Tfh differentiation and function	Baumjohann et al., manuscript submitted
miR-182	Induced by IL-2, promotes clonal expansion	(72)
miR-301a	Promotes Th17 generation and function	(97)
miR-326	Promotes Th17 generation and function in mice. Association of elevated miR-326 expression in blood with multiple sclerosis	(92)