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. Author manuscript; available in PMC: 2013 Jul 1.
Published in final edited form as: IEEE Rev Biomed Eng. 2013;6:29–46. doi: 10.1109/RBME.2012.2215847

Fig. 10.

Fig. 10

(Left) CAD drawing and (Middle) photograph of the portable lensfree super-resolution microscope (weight ~95 grams). The light source consists of 23 LEDs coupled to 23 multi-mode fiber-optic cables without the use of any lenses or other opto-mechanical components. Each LED is sequentially turned on to create subpixel shifted lensfree holograms of the objects on a CMOS sensor-array with 2.2 μm pixel-pitch. These recorded lensfree holograms can be rapidly processed using a pixel-super-resolution algorithm to create lensfree images of the objects with <1 μm resolution over an FOV of >24 mm2. (Right) Reconstructed super-resolved images of standard thin smears of human RBCs that were infected with malaria parasites (Plasmodium falciparum). The parasites can be clearly seen in both amplitude and phase images. Bright-field microscope images (0.65-NA, 40×) of the same samples are also shown. [42] - Reproduced by permission of The Royal Society of Chemistry.