Table 1.

The effect of TCE on the concentration of DA and its metabolites in the substantia nigra and striatum, and the number of tyrosine hydroxylase positive cells in the substantia nigra pars compacta in Fischer 344 rats.

Measurement	Substantia nigra (% control)			Striatum (% control)
Dopamine & metabolites	DA	DOPAC	HVA	DA	DOPAC	HVA
TCE 1 g/kg	80±10*	72±4**	80±5	102±2	62 ±3***	82±3**
6 weeks	(8)	(8)	(8)	(8)	(8)	(8)
	Substantia nigra pars compacta (% control)
Neuronal cell counts	TH+ neurons		Fluorogold neurons
TCE 1 g/kg	55±3**		Reduced
6 weeks	(6)		(3)

The data is from Gash et al. (2008). Control values for dopamine (DA), 3,4-dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA) in the SN and striatum were not given. Control numbers for TH⁺ neurons in the SN were 42,000 ±1000. Fluorogold was given by injection into the striatum retrogradely labeling the neurons in the SN.

Results are Mean ± S.E.M. with the number of animals shown in brackets; values for DA and its metabolites have been read off bar charts, but the statistical analysis is as reported by the authors.

^*p<0.05 compared to control.

^**p<0.01 compared to control.

^***p<0.001 compared to control.