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Reaction mechanism (top) and critical structures (bottom) determined for the second stage of the deacetylation reaction catalyzed by Sir2Tm. INT1': alkylamidate intermediate after nicotinamide release. INT2: bicyclic intermediate. INT3: tetrahedral intermediate. INT4: the protonated tetrahedral intermediate. PRO: 2'-O-AADPR and the deactylated product.
