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. 2004 Mar 15;113(6):924–932. doi: 10.1172/JCI17772

Figure 1.

Figure 1

CD25 DNA vaccination protects against AA. (A) Groups of eight rats each were untreated, vaccinated with the empty vector (pcDNA3), the CD25 gene, or the CD132 gene, prior to AA induction (day 0). AA scores were assessed every day or two starting at day 11. The mean ± SEM disease score is shown. Scores of the CD25-vaccinated group were significantly reduced compared with the pcDNA3 group for each of the days 14–26 (P < 0.01). The P value of day 26 is indicated. This is a representative experiment of three repetitions. (B) Ankle swelling measured at day 26 after AA induction. The results are presented in millimeters, mean ± SEM, measured for the hindlimb ankle diameter. The P value compares the CD25 and pcDNA3 groups.