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Molecular features distinguishing DN, compared to CN and melanoma
| DN | CN | Melanoma | |
|---|---|---|---|
| Proliferation index | + | 0 | +++ |
| BRAF mutation rate | ++ | ++ | ++ |
| Mutation / deletion of p16 gene | + | 0 | +++ |
| Altered expression of p53 | + | + | ++ |
| Loss of PTEN expression | ++ | ++ | +++ |
| Microsatellite instability | + | 0 | +++ |
CN, common nevus; DN, dysplastic nevus
0, absent; +, low rate; ++, detectable with some frequency; +++, high rate or frequency
