Table 2.
Comparison of mouseMAPS in homogenates of untreated or GLV-1h68-treated HCT-116 tumors
| Antigen | Untreated | GLV-1h68 | P value | Ratio |
|---|---|---|---|---|
| CD40 |
31.87 ± 10.5 fg/mg |
193.41 ± 27.53 fg/mg |
** |
6.1 |
| Eotaxin |
1.24 ± 0.67 fg/mg |
371.48 ± 122.26 fg/mg |
* |
300.0 |
| GCP-2 mouse |
0.03 ± 0.009 pg/mg |
0.50 ± 0.29 pg/mg |
* |
19.3 |
| KC/GRO |
0.002 ± 0.001 pg/mg |
0.073 ± 0.018 pg/mg |
** |
34.9 |
| IFN gamma |
1.61 ± 0.03 fg/mg |
7.21 ± 0.35 fg/mg |
*** |
4.5 |
| IP-10 |
2.20 ± 0.71 fg/mg |
145.28 ± 27.64 fg/mg |
** |
66.2 |
| IL-1 alpha |
14.18 ± 2.02 fg/mg |
78.76 ± 7.82 fg/mg |
*** |
5.6 |
| IL-3 |
0.082 ±0.018 fg/mg |
0.45 ± 0.18 fg/mg |
* |
5.5 |
| IL-6 |
1.63 ± 0.57 fg/mg |
20.24 ± 12.76 fg/mg |
|
12.5 |
| IL-10 |
9.89 ± 1.68 fg/mg |
52.48 ± 0.46 fg/mg |
*** |
5.3 |
| IL-11 |
6.03 ± 1.70 fg/mg |
41.71 ± 9.32 fg/mg |
** |
6.9 |
| IL-17A |
5.20 ± 0.93 fg/mg |
52.96 ± 6.40 fg/mg |
*** |
10.2 |
| IL-18 |
1.41 ± 0.08 pg/mg |
8.03 ± 2.33 pg/mg |
* |
5.7 |
| Lymphotactin |
14.25 ± 3.87 fg/mg |
235.25 ± 36.29 fg/mg |
*** |
16.5 |
| M-CSF-1 |
318.57 ± 7.40 fg/mg |
122.67 ± 35.91 fg/mg |
** |
38.5 |
| MIP-1 beta |
25.70 ± 8.90 fg/mg |
1286.62 ± 206.46 fg/mg |
*** |
50.1 |
| MIP-2 |
1.20 ± 0.38 fg/mg |
65.92 ± 30.24 fg/mg |
* |
55.1 |
| MIP-3 |
0.065 ± 0.01 fg/mg |
0.36 ± 0.03 fg/mg |
*** |
5.5 |
| MMP-9 |
9.93 ± 7.02 pg/mg |
91.31 ± 60.77 pg/mg |
|
9.2 |
| MCP-1 |
14.55 ± 4.65 fg/mg |
3332.49 ± 93.80 fg/mg |
*** |
229.1 |
| MCP-3 |
18.20 ± 7.64 fg/mg |
2023.74 ± 386.90 fg/mg |
*** |
111.2 |
| MCP-5 |
11.91 ± 6.71 fg/mg |
676.99 ± 187.73 fg/mg |
** |
56.8 |
| RANTES |
0.0052 ± 0.003 fg/mg |
0.54 ± 0.11 fg/mg |
** |
105.7 |
| TIMP-1 mouse |
1.30 ± 0.22 pg/mg |
12.22 ± 4.53 pg/mg |
* |
9.36 |
| TNF alpha |
5.38 ± 0.59 fg/mg |
23.01 ± 2.51 fg/mg |
*** |
4.27 |
| FGF-b |
107.94 ± 16.12 pg/mg |
69.86 ± 15.26 pg/mg |
* |
1.5 |
| MIP-1 alpha |
0.23 ± 0.008 pg/mg |
0.13 ± 0.034 pg/mg |
* |
1.7 |
| MIP-1 gamma |
0.94 ± 0.15 pg/mg |
0.30 ± 0.03 pg/mg |
** |
3.1 |
| SGOT | 2.08 ± 0.72 pg/mg | 1.08 ± 0.56 pg/mg | 1.9 |
The table compares the levels of mouse immune-related protein antigen profiling in homogenates of untreated and GLV-1h68-treated HCT-116 tumors normalized to total protein per sample 21 days after virus injection [n=3]. The ratio of antigen in GLV-1h68-treated and untreated animals and the level of statistical significance are shown. * = P≤0.05, ** = P≤0.005, *** = P≤0.0005.