Table 3.
GLV-1h68 susceptibility in cell culture and in vivo of CRC cell lines derived from different clinical stages
| Cell line | Clinical stage | GLV-1h68 replication in culture | GLV-1h68 cytotoxicity in culture | GLV-1h68 treatment in xenograft models |
|---|---|---|---|---|
| HCT-116 |
Duke’s type A |
fast |
high |
growth inhibition |
| HT-29 |
Duke’s type B |
fast |
high |
non-responder |
| SW-620 |
Duke’s type C |
slow |
medium |
growth inhibition |
| HCT-15 |
Duke’s type C |
medium |
low |
non-responder |
| Colo 205 | Duke’s type D | fast | high | n.d. |
Comparison of five human CRC cell lines derived from patients at different clinical stage of disease regarding virus susceptibility (replication and cytotoxicity) in cell culture and treatment efficacy in mouse xenograft models of five human CRC cell lines at different clinical stages. n.d. = not determined.