Table 1.
Effect of the combination of tetrandrine and chloroquine against infected chloroquine-resistant Plasmodium falciparum malaria in Aotus monkeys
| Expt. no. | Monkey no. | Dosea (Mg/kg) | Parasites cleared | Days from initial dose to parasite clearance | Days from final dose to recrudescence | Re-treating-post recrudescence (mg/kg) | Cured |
|---|---|---|---|---|---|---|---|
| 1 |
025 |
15(tt) |
+ |
|
|
30 (tt) d |
(++) |
| |
|
20(cq) |
|
16 |
23 |
20 (cq) |
|
| |
055 |
15(tt) |
+ |
|
|
30(tt) d |
(++) |
| |
|
20(cq) |
|
8 |
33 |
20(cq) |
|
| |
016 |
15(tt) |
+ |
|
|
30 (tt) d |
(++) |
| |
|
20(cq) |
|
8 |
13 |
20 (cq) |
|
| 2 |
705 |
30(tt) |
+ |
|
|
60 (tt) d |
(++) |
| |
|
20(cq) |
|
7 |
9 |
20 (cq) |
|
| |
706 |
60(tt) |
+ |
|
|
120 (tt) d |
(++) |
| |
|
20(cq) |
|
7 |
14 |
20 (cq) |
|
| |
698b |
- |
- |
|
|
|
|
| CQc |
520 |
20(cq) |
- |
|
|
|
|
| |
432 |
20(cq) |
- |
|
|
|
|
| |
349 |
20(cq) |
- |
|
|
|
|
| |
544 |
20(cq) |
- |
|
|
|
|
| 631 | 20(cq) | - |
a tt and cq represent tetrandrine and chloroquine respectively.
b This monkey as a non-treated control died within 2 weeks after inoculation with the parasite.
c Monkeys were treated with CQ alone.
d Monkeys were cured after two week combinational cq and tt treatment=(++).