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Regulation of MAT1A in hepatocytes from ASMase knockout mice. ASMase+/+ (A) or ASMase–/– (B) hepatocytes were cultured for 16 hours with TNF-α, bNSMase, or hASMase at the dose shown, and the levels of MAT1A and MAT2A mRNA were determined by Northern blot. The plots (bottom) show the mean ± SD of six to seven individual experiments. *P < 0.05 versus control; denotes significance for MAT1A and MAT2A changes.
