Table 3.
Virulence phenotypes of flagella and chemotaxis mutants of S. Dublin (SDu) and S. Typhimurium (STm) in C57/B6 mice
| Mutant | Challenge routea | CIb S.Du | CIb STm |
|---|---|---|---|
|
cheA |
p.o. |
1.03 |
1.09 |
|
cheB |
p.o. |
0.97 |
1.05 |
|
fliC |
p.o. |
0.46** |
- |
|
fliC |
i.p. |
0.91 |
- |
|
fliC/fljB |
p.o. |
- |
1.12** |
| fliC/fljB | i.p. | - | 1.78*** |
a: p.o. = per oral challenge; i.p. = intraperitoneal challenge.
b: The competitive index was calculated as the ratio of mutant to wild type in the spleen 4–5 days post infection divided by the ratio of mutants to wild type strain in the input pool. Indexes where the output was significantly different from the input pool are marked with ** (p<0.01) and *** (p<0.001).