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. 2013 Mar 26;2013:625892. doi: 10.1155/2013/625892

Figure 6.

Figure 6

Effects of exendin-9 on the acute hypoglycemic effect of WES. Changes in plasma glucose concentration after a single oral dose of WES to high-fat-diet fed mice without (a) or with (b) a prior administration of Exendin-9, a GLP-1 receptor antagonist. Mice were fasted for 6 hr and blood samples collected at time 0. PBS (a) or 0.12 mg/kg BW Exendin-9 (b) were i.p. injected. Five minutes later, WES (3000 mg/kg BW) (S, SE) or vehicle (V, VE) containing equal amount of glucose as in WES (258 mg/kg BW) were administered orally and blood samples collected at the time points indicated. (c) area under curve of (a) and (b). Data are mean ± SD with n = 4 for each group. *P < 0.05 and **P < 0.01 denote significant difference compared to vehicle-treated mice analyzed by Student's t test.