Table 4.
Associations between dietary acrylamide intakes (ng/kcal/day) during pregnancy and birth weight (g).
| Acrylamide intake (ng/kcal/day) | Crude | Adjusteda | ||||
|---|---|---|---|---|---|---|
| β (95% CI) | p-Value | β (95% CI) | p-Value | |||
| All (n = 50,651) | ||||||
| Quartile 1 (< 8.5) | Reference | Reference | ||||
| Quartile 2 (8.50–11.1) | –10.1 | (–23.35, 3.20) | 0.137 | –13.0 | (–23.19, –2.81) | 0.012 |
| Quartile 3 (11.1–14.3) | –15.2 | (–28.43, –1.88) | 0.025 | –20.8 | (–31.05, –10.65) | < 0.001 |
| Quartile 4 (> 14.3) | –21.2 | (–34.44, –7.89) | 0.002 | –25.7 | (–35.89, –15.44) | < 0.001 |
| Acrylamide intake, 1-SD increase | –9.2 | (–13.87, –4.49) | < 0.001 | –9.9 | (–13.50, -6.27) | < 0.001 |
| Nonsmokers (n = 46,420) | ||||||
| Quartile 1 (< 8.4) | Reference | Reference | ||||
| Quartile 2 (8.4–11.0) | –11.0 | (–24.82, 2.83) | 0.119 | –15.9 | (–26.17, –4.94) | 0.004 |
| Quartile 3 (11.0–14.1) | –9.7 | (–23.50, 4.15) | 0.170 | –19.8 | (–30.55, –9.31) | < 0.001 |
| Quartile 4 (> 14.1) | –14.4 | (–28.23, –0.58) | 0.041 | –25.1 | (–35.97, –14.73) | < 0.001 |
| Acrylamide intake, 1-SD increase | –5.8 | (–10.86, –0.92) | 0.020 | –9.6 | (–13.48, –5.84) | < 0.001 |
| Smokers (n = 4,231) | ||||||
| Quartile 1 (< 9.5) | Reference | Reference | ||||
| Quartile 2 (9.5–12.5) | –37.3 | (–84.07, 9.53) | 0.119 | –19.1 | (–55.17, 17.04) | 0.294 |
| Quartile 3 (12.5–16.0) | –45.9 | (–92.66, 0.94) | 0.055 | –31.2 | (–67.40, 5.03) | 0.092 |
| Quartile 4 (> 16.0) | –41.7 | (–88.51, 5.11) | 0.081 | –50.0 | (–86.45, –13.62) | 0.007 |
| Acrylamide intake, 1-SD increase | –12.3 | (–26.96, 2.31) | 0.099 | –12.7 | (–24.12, –1.31) | 0.030 |
| aResults from linear regression model adjusted for gestational age, parity, sex of the child, age of the mother, maternal BMI categorical, maternal gestational weight gain (kg), and smoking during pregnancy. | ||||||