Table 2.
Pathways significantly associated with the predicted targets of miR-125b.
| Canonical pathways | p-Value | miR-125b predicted targets |
|---|---|---|
| Sphingolipid metabolism | 0.003 | ACER2, FUT4, NEU1, SGPL1 |
| Apoptosis signaling | 0.003 | BAK1, CASP2, MAP2K7, MCL1 |
| Glycosphingolipid biosynthesis—globoseries | 0.012 | FUT4, ST8SIA4 |
| Glycosphingolipid biosynthesis—neolactoseries | 0.012 | FUT4, ST8SIA4 |
| Glycosphingolipid biosynthesis—ganglioseries | 0.014 | FUT4, ST8SIA4 |
| N-glycan degradation | 0.014 | MAN1B1, NEU1 |
| O-glycan biosynthesis | 0.017 | FUT4, GCNT1 |
| N-glycan biosynthesis | 0.037 | FUT4, MAN1B1 |
| Sphingosine-1-phosphate signaling | 0.039 | ACER2, CASP2, RND2 |
| TNFR1 | 0.042 | CASP2, TNFAIP3 |
| Semaphorin signaling in neurons | 0.048 | RND2, SEMA4D |
| Abbreviations: ACER2, alkaline ceramidase 2; FUT4, fucosyltransferase 4; GCNT1, glucosaminyl (N-acetyl) transferase 1, core 2; MAN1B1, mannosidase, alpha, class 1B, member 1; NEU1, sialidase 1 (lysosomal sialidase); RND2, Rho family GTPase 2; SEMA4D, sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D; SGPL1, sphingosine-1-phosphate lyase 1; ST8SIA4, ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4; TNFAIP3, tumor necrosis factor, alpha-induced protein 3; TNFR1, tumor necrosis factor binding protein 1. | ||