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. 2004 Mar 15;113(6):856–866. doi: 10.1172/JCI20126

Figure 3.

Figure 3

Elevated levels of autoantibodies 2 weeks after CII immunization in Ccr2–/– mice, as shown by OD measurements in serially diluted serum samples. (A) IgG1 and (B) IgG2a against collagen (mean of three WT and four Ccr2-deficient mice); *P < 0.05. (C) RF was measured in the sera of three WT and four Ccr2–/– mice; **P < 0.0001. Collagen-specific IgG quantification was performed in several experiments, and Ccr2–/– mice consistently had higher IgG levels than the WT littermates before arthritic disease was clinically evident, and those levels remained elevated after the arthritic disease started (data not shown).