Table 2.
Statistics of the 15 STR loci of Plasmodium falciparum-positive individuals: mutants to PYR
Microsatellites |
Sampled populations - Miyobo |
Sampled populations - Ngonamanga |
|||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
Single mutant |
Double mutant |
Triple mutant |
All samples |
Triple mutant |
||||||||
|
( N =10) |
(N=37) |
(N=17) |
(N=64) |
(N=82) |
||||||||
Rs | He | Rs | He | Rs | He | Rs | He | FST | P | Rs | He | ||
Loci flanking dhfr gene |
Dhfr 0.3 |
3 |
0.51 |
3 |
0.32 |
2 |
0.15 |
3 |
0.33 |
0.02 |
NS |
7 |
0.26 |
Dhfr 4.4 |
1 |
0.00 |
2 |
0.14 |
2 |
0.17 |
2 |
0.10 |
-0.04 |
NS |
3 |
0.10 |
|
Dhfr 5.3 |
3 |
0.56 |
2 |
0.18 |
1 |
0.00 |
2 |
0.24 |
0.10 |
0.03 |
3 |
0.08 |
|
All loci |
2 |
0.36 |
2 |
0.21 |
2 |
0.11 |
2 |
0.22 |
0.03 |
0.05 |
4 |
0.15 |
|
Neutral loci |
TA1 |
4 |
0.82 |
5 |
0.83 |
6 |
0.89 |
6 |
0.85 |
0.04 |
0.04 |
12 |
0.87 |
TA102 |
4 |
0.64 |
7 |
0.88 |
5 |
0.84 |
6 |
0.79 |
0.03 |
NS |
8 |
0.78 |
|
ARA2 |
4 |
0.69 |
5 |
0.77 |
6 |
0.79 |
5 |
0.75 |
-0.03 |
NS |
9 |
0.81 |
|
TA87 |
4 |
0.87 |
6 |
0.85 |
5 |
0.81 |
6 |
0.84 |
0.01 |
NS |
9 |
0.84 |
|
PfPK2 |
5 |
0.93 |
6 |
0.86 |
5 |
0.85 |
6 |
0.88 |
-0.03 |
NS |
12 |
0.87 |
|
TA81 |
4 |
0.87 |
5 |
0.81 |
4 |
0.71 |
5 |
0.80 |
-0.04 |
NS |
10 |
0.87 |
|
TA42 |
3 |
0.60 |
2 |
0.11 |
2 |
0.28 |
2 |
0.32 |
0.06 |
NS |
8 |
0.36 |
|
Pfg377 |
3 |
0.67 |
3 |
0.56 |
3 |
0.65 |
3 |
0.62 |
-0.04 |
NS |
7 |
0.55 |
|
TA109 |
5 |
0.86 |
5 |
0.80 |
4 |
0.79 |
5 |
0.82 |
0.04 |
0.03 |
8 |
0.75 |
|
All loci | 4 | 0.77 | 5 | 0.72 | 4 | 0.73 | 5 | 0.74 | <0.01 | NS | 9 | 0.74 |
N: number of isolates genotyped, He: expected heterozygosity; Rs: allelic richness. All loci: mean over loci Rs and He and global Fst over loci as calculated by FSTAT. P:P-values of permutation tests to assess significance of Fst values. NS: non-significant (P>0.05).