Table 3.
Statistics of the 15 STR loci of Plasmodium falciparum-positive individuals: mutants to SFX
Microsatellites |
Sampled populations - Miyobo |
Sampled populations - Ngonamanga |
|||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
Single mutant |
Double mutant |
All samples ( N =60) |
Double mutant |
Triple mutant |
All samples (N=85) |
|||||||||||
|
|
|
|
(N=63) |
(N=22) |
|
|||||||||||
|
(N=17) |
( N =43) |
|
||||||||||||||
Rs | He | Rs | He | Rs | He | FST | P | Rs | He | Rs | He | Rs | He | FST | P | ||
Loci flanking dhps gene |
Dhps 0.8 |
4 |
0.60 |
5 |
0.75 |
5 |
0.67 |
0.02 |
NS |
9 |
0.81 |
5 |
0.64 |
9 |
0.73 |
0.06 |
0.01 |
Dhps 4.3 |
6 |
0.83 |
5 |
0.77 |
6 |
0.80 |
<0.01 |
NS |
7 |
0.78 |
4 |
0.71 |
7 |
0.75 |
0.13 |
<0.01 |
|
Dhps 7.7 |
6 |
0.79 |
7 |
0.84 |
8 |
0.82 |
0.09 |
<0.01 |
10 |
0.85 |
6 |
0.67 |
10 |
0.76 |
0.14 |
<0.01 |
|
All loci |
5 |
0.74 |
6 |
0.79 |
6 |
0.76 |
0.04 |
<0.01 |
9 |
0.81 |
5 |
0.67 |
9 |
0.74 |
0.11 |
<0.01 |
|
Neutral loci |
TA1 |
5 |
0.79 |
8 |
0.87 |
8 |
0.83 |
0.04 |
NS |
9 |
086 |
8 |
0.88 |
9 |
0.87 |
<0.01 |
NS |
TA102 |
5 |
0.78 |
9 |
0.87 |
9 |
0.83 |
0.04 |
0.01 |
6 |
0.75 |
7 |
0.86 |
7 |
0.80 |
<-0.01 |
NS |
|
ARA2 |
6 |
0.79 |
6 |
0.69 |
7 |
0.74 |
0.06 |
<0.01 |
7 |
0.80 |
6 |
0.82 |
7 |
0.81 |
-0.01 |
NS |
|
TA87 |
5 |
0.79 |
8 |
0.84 |
7 |
0.82 |
0.05 |
0.02 |
8 |
0.83 |
7 |
0.87 |
8 |
0.85 |
0.02 |
NS |
|
PfPK2 |
5 |
0.83 |
8 |
0.80 |
8 |
0.81 |
0.11 |
0.02 |
10 |
0.87 |
8 |
0.87 |
11 |
0.87 |
0.02 |
<0.05 |
|
TA81 |
5 |
0.77 |
6 |
0.78 |
7 |
0.78 |
-0.02 |
NS |
9 |
0.88 |
8 |
0.83 |
9 |
0.85 |
<0.01 |
NS |
|
TA42 |
1 |
0.00 |
4 |
0.29 |
3 |
0.14 |
0.03 |
NS |
5 |
0.44 |
3 |
0.18 |
5 |
0.31 |
0.05 |
0.04 |
|
Pfg377 |
3 |
0.56 |
4 |
0.59 |
3 |
0.57 |
<-0.01 |
NS |
5 |
0.59 |
3 |
0.40 |
5 |
0.50 |
0.01 |
NS |
|
TA109 |
6 |
0.86 |
6 |
0.81 |
6 |
0.83 |
-0.02 |
NS |
5 |
0.72 |
5 |
0.60 |
6 |
0.66 |
0.16 |
<0.01 |
|
All loci | 5 | 0.69 | 6 | 0.73 | 6 | 0.71 | 0.03 | <0.01 | 7 | 0.75 | 6 | 0.70 | 7 | 0.72 | 0.03 | 0.01 |
N: number of isolates genotyped, He: expected heterozygosity; Rs: allelic richness. All loci: mean over loci Rs and He and global Fst over loci as calculated by FSTAT. P:P-values of permutation tests to assess significance of Fst values. NS: non-significant (P>0.05).