Table 2.
Overview of the most relevant cellular functions affected by elevated pressure alone and by elevated pressure and DOT
|
Cellular function |
Differentially expressed genes |
|
|---|---|---|
| Pressure | Pressure oxygen | |
| Stress sensing/stress response |
• aer-1 (-), MCP (-) |
• aer-1 (-), MCP (-) |
| |
• rpoH and heat-shock genes (+) |
• rpoH and heat-shock genes (+) |
| |
• DNA repair (-) |
• DNA repair (-) |
| Control of reactive oxygen species |
• ahpC, glutathione genes (+) |
• ahpC, glutathione genes (+) |
| |
• anr (+) and cyo (+) |
• anr (-) and cyo (+) |
| |
• Cbb3-1 (+), Cbb3-2 (-), Aa3 (-), Cyo (+), azu (+) |
• Cbb3-1 (-), Cbb3-2 (-), Aa3 (-), Cyo (+), azu (-) |
| Cell envelope |
• oprG (+), oprH (+) |
• oprG (-), oprH (+) |
| |
• membrane proteins |
• membrane proteins |
| |
• secretion systems (+) |
• secretion systems (+) |
| Internal pH |
• urease (+) |
• secretion systems (+) |
| |
• secretion systems (+) |
|
| |
• oxidative stress (+) |
• oxidative stress (+) |
| Fe homeostasis/Fe-S clusters |
• siderophore transporters (+), bacterioferritin (-) |
|
| |
|
• siderophore transporters (+), bacterioferritin (-) |
| Biosynthetic metabolism |
|
• ADI (-) |
| • Glu synthesis/metabolism (+) | ||
Induction and repression of gene transcription is indicated by the signs (+) and (-), respectively, and major differences of gene transcription between the two conditions are indicated by the bold font. Abbreviations: ADI, arginine deiminase pathway; Glu, glutamate; MCP, methyl-accepting chemotaxis protein.