Table 4.
Association between MDM2 SNP309 and gastric carcinoma in relation to location, metastasis and TNM stage
|
Variable |
MDM2 SNP309 genotype (Control/Case) |
Adjusted OR (95% CI) † |
P value |
||
|---|---|---|---|---|---|
| TT + TG | GG | TT + TG | GG | ||
| Location |
|
|
|
|
|
| Cardia |
495/141 |
79/40 |
1.00 |
1.84 (1.20-2.83) |
< 0.01 |
| Non-cardia |
495/292 |
79/101 |
1.00 |
2.18 (1.57-3.04) |
< 0.01 |
| Vascular invasion |
|
|
|
|
|
| Absent |
495/265 |
79/98 |
1.00 |
2.33 (1.67-3.26) |
< 0.01 |
| Present |
495/168 |
79/43 |
1.00 |
1.60 (1.06-2.42) |
0.03 |
| Lymph node metastasis |
|
|
1.00 |
|
|
| Absent |
495/138 |
79/35 |
1.00 |
1.59 (1.02-2.47) |
0.04 |
| Present |
495/295 |
79/106 |
1.00 |
2.25 (1.63-3.12) |
< 0.01 |
| Liver metastasis |
|
|
1.00 |
|
|
| Absent |
495/391 |
79/121 |
1.00 |
1.94 (1.42-2.65) |
< 0.01 |
| Present |
495/42 |
79/20 |
1.00 |
3.34 (1.84-6.08) |
< 0.01 |
| Peritoneal dissemination |
|
|
|
|
|
| Absent |
495/380 |
79/123 |
1.00 |
2.04 (1.49-2.79) |
< 0.01 |
| Present |
495/53 |
79/18 |
1.00 |
2.13 (1.18-3.84) |
0.01 |
| TNM stage |
|
|
|
|
|
| IA |
495/75 |
79/21 |
1.00 |
1.75 (1.01-3.00) |
0.04 |
| IB |
495/60 |
79/19 |
1.00 |
2.01 (1.13-3.57) |
0.01 |
| II |
495/83 |
79/24 |
1.00 |
1.78 (1.06-2.98) |
0.03 |
| III |
495/127 |
79/46 |
1.00 |
2.30 (1.52-3.49) |
< 0.01 |
| IV | 495/88 | 79/31 | 1.00 | 2.29 (1.42-3.69) | < 0.01 |
†Adjusted for age, sex, and H. pylori infection.
Abbreviations: OR, odds ratio; CI, confidence interval.