Table 1.

Water solubility, the partition coefficient (log P), and peritoneal to plasma drug area under the curve (AUC) ratio of intraperitoneal chemotherapeutic agents.

Chemotherapeutic agent	Molecular weight	Water solubility	log P	Peritoneal to plasma AUC ratio
Cisplatin	300	Good	−2.19	12
Carboplatin	371	Good	1.06	10–18
Oxaliplatin	397	Good	1.73	16
Paclitaxel	854	Poor	3.54	1000
Docetaxel	862	Poor	2.92	181
5-Fluorouracil	130	Sparing	-0.89	367
Doxorubicin	544	Poor	1.27	474