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Evaluation biomarker performance using ROC analysis. (A) ROC analysis of urinary biomarkers (KIM-1, NAG, and total protein) in mice subjected to ischemia/reperfusion over different degrees of histological injury (histopathology score 0–1, histopathology score 0–2, and histopathology score 0–3). (B) Performance of biomarkers, including sCr, uKIM-1 (absolute and normalized), NAG (normalized), and proteinuria (normalized) in detecting kidney injury over different histological grades.
